GHRP-2

GHRP-2

GHRP-2 (Growth Hormone-Releasing Peptide 2) is a synthetic hexapeptide GH secretagogue and ghrelin receptor (GHSR-1a) agonist. It is one of the most potent and well-characterized GH-releasing peptides available, producing robust GH secretion with a pharmacological profile distinct from GHRP-6. GHRP-2 is particularly valued for its effects on appetite regulation, body composition, and its interactions with the melanocortin system.

How It Works

GHRP-2 activates GHSR-1a through Gq protein-coupled signaling, triggering GH exocytosis from pituitary cells:

• GH Pulse Stimulation:: Produces potent, dose-dependent GH release with activity at both pituitary and hypothalamic sites

• Appetite Regulation:: GHSR-1a activation in hypothalamic appetite-regulating circuits influences food intake and neuropeptide Y (NPY) expression

• Melanocortin System:: Interacts with the melanocortin system, influencing POMC and AgRP expression relevant to body composition

• IGF-1 Axis:: GH release drives hepatic IGF-1 production, activating downstream anabolic and metabolic signaling

• Body Composition:: Supports lean mass while promoting fat metabolism through GH/IGF-1 axis activation

Key Benefits

• Powerful GH Stimulation:: Among the most potent GH secretagogues available

• Appetite Support:: Supports healthy appetite regulation through ghrelin receptor activation

• Body Composition:: Supports lean mass and fat metabolism through GH/IGF-1 axis

• Performance:: Supports muscle growth, recovery, and metabolic performance

Structural Properties

GHRP-2 has a molecular weight of 817.9 Da with the sequence D-Ala-D-βNal-Ala-Trp-D-Phe-Lys (CAS: 158861-67-7). Purity ≥99.0%.

Quality and Purity

Supplied as a lyophilized powder with purity ≥99.0% verified by HPLC and mass spectrometry. Each vial contains 5 mg.

Storage

Store at −20°C. Stable for 24 months.