IGF-1 LR3

IGF-1 LR3

IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a recombinant analogue of human IGF-1, engineered with modifications that dramatically reduce binding to IGF-binding proteins (IGFBPs), resulting in a significantly extended half-life. This means more of the peptide remains biologically active, delivering sustained anabolic signaling for muscle growth and recovery.

How It Works

IGF-1 LR3 binds to the IGF-1 receptor (IGF-1R), activating two major downstream pathways: the PI3K/Akt/mTOR pathway (driving protein synthesis and cell survival) and the Ras/MAPK/ERK pathway (regulating cell proliferation and differentiation). Its reduced IGFBP binding means greater potency and duration compared to native IGF-1.

Key Benefits

• Sustained Anabolic Signaling:: Extended half-life (20–30 hours) delivers prolonged muscle-building support

• Protein Synthesis:: Activates mTOR-dependent protein synthesis for lean mass development

• Muscle Cell Growth:: Supports myoblast differentiation, satellite cell activation, and myotube formation

• Recovery:: Promotes cellular repair and nitrogen retention following intense training

Structural Properties

IGF-1 LR3 has a molecular weight of approximately 9,200 Da, produced via recombinant E. coli expression. The R3 substitution reduces IGFBP-3 binding by ~1000-fold while maintaining full IGF-1R binding potency.

Quality and Purity

Supplied as a lyophilized powder with purity ≥98.0% verified by HPLC and mass spectrometry. Each vial contains 1 mg.

Storage

Store at −80°C. Single-use aliquots recommended. Stable for 12 months under proper storage conditions.