Sermorelin

Sermorelin

Sermorelin (GHRH 1-29 NH₂) is a synthetic analogue of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH), representing the minimal active fragment required for full biological activity at the GHRH receptor. As the prototypical GHRH analogue, Sermorelin stimulates pituitary somatotroph cells to secrete growth hormone in a physiologically pulsatile manner — supporting muscle growth, recovery, and healthy aging.

How It Works

Sermorelin exerts its benefits through highly specific receptor-mediated signaling:

• GHRH Receptor Binding:: Binds with high affinity to the GHRH receptor on pituitary cells, activating adenylyl cyclase and triggering a cAMP-dependent cascade that drives GH synthesis and secretion

• Pulsatile GH Release:: Stimulates pulsatile GH release that mirrors the physiological secretory pattern, preserving the natural GH signaling required for downstream IGF-1 production

• IGF-1 Support:: Sermorelin-stimulated GH release drives hepatic IGF-1 production and downstream anabolic signaling

• Synergistic Stacking:: Acts synergistically with ghrelin mimetics (GHRP-2, GHRP-6, Ipamorelin) to amplify GH release beyond what either compound achieves alone

• Calcium Mobilization:: Also activates phospholipase C through Gq-coupled signaling, further amplifying GH secretion

Key Benefits

• Natural GH Support:: Stimulates physiologically pulsatile GH release for natural-pattern support

• Muscle Growth:: GH/IGF-1 elevation supports lean mass development and protein synthesis

• Recovery:: Supports tissue repair, nitrogen retention, and anabolic recovery

• Anti-Aging:: Supports the GH axis as a key regulator of healthy aging

Structural Properties

Sermorelin has a molecular weight of 3357.9 Da (CAS: 86168-78-7). The C-terminal amidation is essential for receptor binding affinity and biological activity.

Quality and Purity

Supplied as a lyophilized powder with purity ≥98.0% verified by HPLC and mass spectrometry. Each vial contains 2 mg.

Storage

Store at −20°C. Stable for 24 months.