Ipamorelin

Ipamorelin

Ipamorelin is a synthetic pentapeptide GH secretagogue and selective ghrelin receptor agonist. It is distinguished from other GH-releasing peptides by its exceptional selectivity — producing clean GH release with minimal stimulation of cortisol, prolactin, or ACTH. This makes it one of the most popular GH secretagogues for those seeking muscle support and recovery without unwanted hormonal side effects.

How It Works

Ipamorelin binds to the ghrelin receptor (GHSR-1a) on pituitary cells, activating calcium-dependent signaling that triggers GH release. Its high receptor selectivity means it produces GH pulses without significantly elevating cortisol or prolactin — delivering the benefits of GH stimulation with a clean hormonal profile.

Key Benefits

• Clean GH Release:: Selective GH stimulation without cortisol or prolactin elevation

• Muscle Support:: GH-driven IGF-1 elevation supports lean mass and protein synthesis

• Recovery:: Supports tissue repair, collagen synthesis, and anabolic recovery

• Sleep Quality:: Often used before sleep to support natural nocturnal GH pulses

• Ideal Stack Partner:: Pairs with CJC-1295 (No DAC) for amplified, clean GH pulses

Structural Properties

Ipamorelin has a molecular weight of 711.9 Da with the sequence Aib-His-D-2-Nal-D-Phe-Lys (CAS: 170851-70-4). D-amino acids and Aib contribute to metabolic stability and receptor selectivity.

Quality and Purity

Supplied as a lyophilized powder with purity ≥99.0% verified by HPLC and mass spectrometry. Each vial contains 5 mg.

Storage

Store at −20°C. Stable for 24 months as lyophilized powder.