TB-500

TB-500

TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), one of the most abundant intracellular peptides in the human body. It plays a central role in actin dynamics, cell motility, and tissue repair — making it one of the most versatile healing and recovery peptides available.

How It Works

TB-500's primary function is G-actin sequestration — binding to monomeric actin to regulate the balance between G-actin and F-actin within cells. This regulation of actin dynamics drives:

• Cell Migration:: Facilitates the movement of endothelial cells, keratinocytes, and fibroblasts to injury sites

• Angiogenesis:: Stimulates new blood vessel formation by promoting endothelial cell migration and tube formation

• Anti-Inflammatory:: Downregulates inflammatory cytokines and modulates macrophage activity

• Stem Cell Activation:: May activate tissue-resident progenitor cells to support regeneration

Key Benefits

• Systemic Healing:: Supports healing across multiple tissue types — muscle, tendon, skin, cardiac

• Accelerated Recovery:: Promotes faster wound closure and tissue remodeling

• Anti-Inflammatory:: Helps resolve inflammation and support the transition to repair

• Synergistic with BPC-157:: Commonly stacked for comprehensive healing support

Structural Properties

TB-500 has a molecular weight of 4963.5 Da (CAS: 77591-33-4), produced synthetically to match the actin-binding domain of Thymosin Beta-4.

Quality and Purity

Supplied as a lyophilized powder with purity ≥98.5% verified by HPLC and mass spectrometry. Each vial contains 5 mg.

Storage

Store at 2–8°C. Protect from light. Stable for 24 months.