MGF (Mechano Growth Factor)

MGF (Mechano Growth Factor)

MGF (Mechano Growth Factor) is a splice variant of insulin-like growth factor 1 (IGF-1) that is generated in response to mechanical overload, exercise, or tissue injury. Unlike systemic IGF-1, MGF is produced locally in mechanically stressed or injured muscle tissue and acts in an autocrine/paracrine manner to activate satellite cells and initiate muscle repair.

How It Works

MGF's muscle repair benefits are mediated through a distinct mechanism from systemic IGF-1: - **Satellite Cell Activation:** MGF's unique C-terminal E-domain activates quiescent satellite cells — the muscle stem cells responsible for muscle repair and regeneration

• Myoblast Proliferation:: Stimulates myoblast proliferation through IGF-1 receptor-dependent mechanisms, expanding the pool of myogenic precursor cells

• Mechanotransduction:: Links mechanical stimuli to anabolic and repair signaling in muscle tissue

• Anti-Apoptotic Effects:: Activates PI3K/Akt survival signaling in muscle cells, reducing apoptosis following injury

• Protein Synthesis:: Through IGF-1R and downstream mTOR activation, promotes protein synthesis in muscle cells

Key Benefits

• Muscle Repair:: Activates satellite cells for comprehensive muscle repair and regeneration

• Recovery Acceleration:: Supports faster recovery from intense training and muscle injury

• Lean Mass Support:: Promotes protein synthesis and muscle cell growth

• Mechanotransduction:: Responds to mechanical loading to drive adaptive muscle growth

Structural Properties

MGF has a molecular weight of 2867.3 Da. The unique C-terminal E-domain sequence distinguishes MGF from systemic IGF-1. Purity ≥95.0%.

Quality and Purity

Supplied as a lyophilized powder with purity ≥95.0% verified by HPLC and mass spectrometry. Each vial contains 2 mg.

Storage

Store at −20°C. Stable for 24 months.