PEG-MGF

PEG-MGF

PEG-MGF is a PEGylated form of Mechano Growth Factor, in which polyethylene glycol (PEG) chains are covalently attached to the MGF peptide to dramatically extend its half-life. While native MGF has a very short half-life due to rapid enzymatic degradation, PEGylation protects the peptide from proteolytic cleavage, enabling sustained biological activity for comprehensive muscle repair support.

How It Works

PEG-MGF retains the biological activity of native MGF while offering a dramatically extended pharmacokinetic profile:

• Extended Satellite Cell Activation:: The prolonged half-life allows for sustained satellite cell activation over extended time periods, supporting the full arc of muscle repair

• Sustained Myoblast Proliferation:: Provides continuous IGF-1R stimulation, supporting sustained myoblast proliferation and myogenic precursor cell expansion

• Prolonged Anabolic Signaling:: Sustained mTOR activation supports protein synthesis rates and muscle fiber development

• Comprehensive Recovery:: Extended activity covers multiple phases of the muscle repair cascade

Key Benefits

• Extended Recovery Support:: Longer half-life provides sustained muscle repair signaling

• Comprehensive Muscle Repair:: Supports the full temporal arc of satellite cell activation and muscle regeneration

• Convenient Dosing:: Extended half-life reduces the need for frequent administration

• Synergistic:: Pairs with BPC-157 for comprehensive recovery support

Structural Properties

PEG-MGF has an approximate molecular weight of 7000 Da (including PEG chains). The PEG modification significantly increases hydrodynamic radius, reducing renal filtration and proteolytic susceptibility. Purity ≥95.0%.

Quality and Purity

Supplied as a lyophilized powder with purity ≥95.0% verified by HPLC and mass spectrometry. Each vial contains 2 mg.

Storage

Store at −20°C. Stable for 24 months.