Dihexa

Dihexa

Dihexa is a small peptide derived from angiotensin IV, engineered to activate hepatocyte growth factor (HGF) signaling through the MET receptor. It has attracted significant interest for its extraordinarily potent effects on synaptogenesis and memory formation — with reported potency orders of magnitude greater than BDNF in some assays.

How It Works

Dihexa activates the HGF/MET signaling pathway, triggering downstream cascades including PI3K/Akt, MAPK/ERK, and STAT3:

• Synaptogenesis:: Potently stimulates the formation of new synaptic connections, increasing dendritic spine density and synaptic protein expression

• Dendritic Spine Density:: Increases the density of dendritic spines — the structural correlates of synaptic connections — in hippocampal neurons

• Memory Circuit Enhancement:: Supports hippocampal-dependent memory formation and consolidation

• Hippocampal Neurogenesis:: May promote neurogenesis in the hippocampal dentate gyrus

Key Benefits

• Powerful Memory Support:: Exceptionally potent synaptogenic activity for memory enhancement

• Cognitive Enhancement:: Supports learning, memory formation, and recall

• Neuroprotection:: HGF/MET signaling provides neuroprotective benefits

• Synapse Formation:: Promotes new synaptic connections for enhanced neural connectivity

Structural Properties

Dihexa has a molecular weight of 594.7 Da (CAS: 1401708-83-5). Its small size and lipophilic character facilitate CNS penetration. Purity ≥98.0%.

Quality and Purity

Supplied as a lyophilized powder with purity ≥98.0% verified by HPLC and mass spectrometry. Each vial contains 10 mg.

Storage

Store at −20°C. Stable for 24 months.