Semax

Semax

Semax is a synthetic heptapeptide analogue of the ACTH(4-10) fragment, developed for neuroprotection and cognitive support. Its sequence — Met-Glu-His-Phe-Pro-Gly-Pro — is derived from adrenocorticotropic hormone (ACTH) but lacks adrenal-stimulating activity, making it a selective cognitive support peptide. Semax is widely used for its effects on BDNF synthesis, dopaminergic modulation, and memory enhancement.

How It Works

Semax supports cognitive function through several neurobiological mechanisms:

• BDNF Upregulation:: Significantly increases brain-derived neurotrophic factor (BDNF) expression — a critical regulator of synaptic plasticity, neuronal survival, and memory consolidation

• Dopaminergic Support:: Influences dopamine receptor expression and dopaminergic neurotransmission in areas relevant to attention and executive function

• Serotonergic Effects:: Modulates serotonin receptor expression and serotonin transporter activity

• Neuroprotection:: Protective effects against oxidative stress and excitotoxicity in neuronal cells

• Hippocampal Plasticity:: Supports long-term potentiation (LTP) and spatial memory-related neural circuits

Key Benefits

• Memory Enhancement:: Supports memory consolidation, recall, and learning

• Mental Clarity:: Sharpens focus and cognitive performance

• Neuroprotection:: Protects neurons against oxidative stress and damage

• BDNF Support:: Promotes neuroplasticity and long-term brain health

Structural Properties

Semax has a molecular weight of 813.9 Da (CAS: 80714-61-0). The C-terminal Pro-Gly-Pro extension confers resistance to enzymatic degradation. Purity ≥99.0%.

Quality and Purity

Supplied as a lyophilized powder with purity ≥99.0% verified by HPLC and mass spectrometry. Each vial contains 30 mg.

Storage

Store at −20°C. Protect from light. Stable for 24 months.