Epithalon

Epithalon

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, developed based on the natural peptide Epithalamin from the bovine pineal gland. It is one of the most studied peptides in longevity and anti-aging wellness, particularly for its ability to support telomere health and cellular longevity.

How It Works

Epithalon's primary mechanism of interest is its ability to stimulate telomerase activity — the enzyme that adds protective telomeric DNA repeats to chromosome ends, counteracting the progressive telomere shortening that occurs with each cell division. Additional benefits include:

• Telomere Support:: Activates telomerase in somatic cells, supporting telomere length and extended cellular vitality

• Pineal Gland Support:: Influences melatonin synthesis regulation and circadian rhythm modulation

• Antioxidant Activity:: Enhances antioxidant enzyme activity, reducing oxidative damage to cellular components

• Gene Expression:: Modulates genes involved in cell cycle regulation, DNA repair, and cellular health

Key Benefits

• Cellular Longevity:: Supports telomere health and cellular vitality at the molecular level

• Anti-Aging:: Addresses biological aging mechanisms at the cellular level

• Sleep & Circadian Support:: Supports pineal gland function and melatonin production

• Antioxidant Defense:: Reduces oxidative stress associated with aging

Structural Properties

Epithalon has a molecular weight of 390.4 Da (CAS: 307297-39-8). Its small tetrapeptide size facilitates cellular uptake and nuclear localization.

Quality and Purity

Supplied as a lyophilized powder with purity ≥99.0% verified by HPLC and mass spectrometry. Each vial contains 10 mg.

Storage

Store at −20°C. Stable for 24 months.