GHK-Cu Skin

GHK-Cu Skin

GHK-Cu (Copper Peptide GHK-Cu, Copper Tripeptide-1) is a naturally occurring copper complex of the tripeptide Gly-His-Lys, first isolated from human plasma albumin. It is one of the most extensively studied peptides in skin biology, with a remarkable breadth of benefits spanning fibroblast activation, collagen and elastin synthesis, antioxidant defense, anti-inflammatory signaling, and gene expression modulation.

How It Works

GHK-Cu delivers its skin benefits through multiple, well-characterized mechanisms:

• Copper Delivery:: The GHK tripeptide chelates copper(II) ions, facilitating copper delivery to copper-dependent enzymes including lysyl oxidase (collagen/elastin crosslinking) and superoxide dismutase (antioxidant defense)

• Fibroblast Activation:: Stimulates dermal fibroblast proliferation, migration, and synthetic activity — increasing collagen I, collagen III, elastin, fibronectin, and decorin production

• TGF-β Modulation:: Modulates TGF-β signaling to promote collagen synthesis in normal fibroblasts while reducing fibrosis in scar tissue

• Antioxidant Defense:: Upregulates antioxidant enzymes including SOD, catalase, and glutathione peroxidase, reducing oxidative damage from UV exposure and aging

• Anti-Inflammatory:: Reduces pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and modulates NF-κB signaling

• Gene Expression Reprogramming:: Modulates the expression of over 4,000 genes in human fibroblasts, reversing age-related gene expression changes

Key Benefits

• Collagen & Elastin Boost:: Stimulates collagen I, III, and elastin synthesis for firmer, more youthful skin

• Visible Anti-Aging:: Reverses age-related gene expression changes in skin cells

• Antioxidant Protection:: Neutralizes free radicals that accelerate skin aging

• Skin Repair:: Accelerates healing and reverses damage from UV exposure and environmental stressors

Structural Properties

GHK-Cu has a molecular weight of 403.9 Da (complex) (CAS: 89030-95-5). Purity ≥98.0%.

Quality and Purity

Supplied as a lyophilized powder with purity ≥98.0% verified by HPLC and mass spectrometry. Each vial contains 50 mg.

Storage

Store at −20°C. Protect from light. Stable for 24 months.