GHK-Cu (Copper Peptide)

GHK-Cu (Copper Peptide)

GHK-Cu (Glycyl-L-Histidyl-L-Lysine copper complex) is a naturally occurring copper-binding tripeptide found in human plasma. It is one of the most extensively studied peptides in skin biology, with a remarkable breadth of documented benefits spanning collagen synthesis, wound healing, antioxidant defense, and gene expression regulation. Its natural origin and well-characterized safety profile make it a foundational compound in anti-aging skincare.

How It Works

GHK-Cu exerts its skin benefits through multiple mechanisms:

• Collagen Synthesis:: Upregulates collagen types I, III, and IV in dermal fibroblasts, along with elastin and proteoglycans — the structural proteins that maintain skin architecture and elasticity

• Antioxidant Defense:: The copper ion participates in superoxide dismutase (SOD) activity, neutralizing free radicals that contribute to skin aging

• Wound Healing:: Accelerates wound closure by stimulating fibroblast proliferation, migration, and collagen deposition

• Gene Expression:: Modulates hundreds of genes involved in tissue remodeling, inflammation, and cellular repair

• Anti-Inflammatory:: Downregulates TNF-α and other pro-inflammatory cytokines

Key Benefits

• Visible Anti-Aging:: Stimulates collagen and elastin for firmer, more youthful skin

• Skin Repair:: Accelerates healing and reverses damage from UV exposure and environmental stressors

• Antioxidant Protection:: Neutralizes free radicals that accelerate skin aging

• Skin Texture:: Improves skin smoothness, radiance, and overall appearance

Structural Properties

GHK-Cu has a molecular weight of 340.4 Da (CAS: 89030-95-5). The copper(II) ion is coordinated through the histidine imidazole nitrogen.

Quality and Purity

Supplied as a lyophilized powder with purity ≥98.5% verified by HPLC and mass spectrometry. Each vial contains 50 mg.

Storage

Store at 4°C. Stable for 24 months.